The C allele of rs2282151 in NFKBIE was associated with a significantly increased risk of CRC (OR = 1.24; 95 % CI: 1.08–1.42 in the discovery stage (P = 0.002) and 1.39 (95 % CI: 1.14–1.70) in replication stage (P = 0.001), respectively. This evidence concerns the gene NFKBIE and colorectal carcinoma.