Four SNPs, including STAT3 rs1053005, CXCL12 rs1029153, NFKBIA rs1022714, and NFKBIE rs2282151 were found nominally associated (P < 0.05) with CRC risk via logistic regression in an additive model adjusted for age and gender (Additional file 1: Table S1). Here, STAT3 is linked to colorectal carcinoma.