Furthermore, 20-hydroxyeicosatetraenoic acid (20-HETE) has renoprotective actions in hypertension, and mutations in CYP4A11 that produces 20-HETE have been linked to elevated blood pressure in humans [29, 30], indicating the important role of CYP4A11 in HTN. The gene discussed is CYP4A11; the disease is hypertensive disorder.