Exploratory analysis applying to ApoE regression dilution ratios calculated by the CRP-CHD Genetics Consortium for another blood-based biomarker, CRP (where the regression dilution ratio adjusted for age and sex was 0.57, 95% CI 0.51, 0.64) [27], indicated that the effect of regression to the mean is unlikely to have a major effect on the observed association, with the odds of CVD for a 1-SD increase in ApoE increasing from 1.02 to 1.035. This evidence concerns the gene APOE and coronary artery disorder.