FMR1 and fragile X-associated tremor/ataxia syndrome: Although the presence of an unmethylated FM could mean that FMRP is still produced, albeit at a lower amount due to the inefficient translation of the FMR1 transcripts containing a hyperexpanded CGG-repeat stretch [26], the FMR1 mRNA levels are generally higher in individuals with an unmethylated FM [25], which increases their risk of developing FXTAS [27,28,29].