However, several key issues related to predictive testing for the late-onset, PM-related FXTAS/FXPOI in newborns, identification of FM girls who may or may not develop the symptoms of FXS, and genetic counseling problems for the complex phenotypic spectrum of FMR1-related conditions, still remain to be fully addressed. Here, FMR1 is linked to fragile X-associated tremor/ataxia syndrome.