Later, ENU mutagenesis screens produced two independent point mutations in the stem domain of Dync1h1. Legs-at-odd-angles (Loa) and Cramping1 (Cra1) heterozygous mice display a dominant motor weakness and sensory neuropathy phenotype characterized by a massive decrease in motor neurons (20%–50%) by gestational age E18.5 leading to paralysis and death within 24 h [20,21]. This evidence concerns the gene DYNC1H1 and sensory peripheral neuropathy.