Table 4 presents data of genetic frequencies for smokers stratified by smoking duration as a categorical variable (<20 YS/≥20 YS). Among smokers ≥20 YS, only CYP1A1 Ile462Ile was associated with the greater risk of breast cancer (OR = 7.12 (1.98–25.59)). The gene discussed is CYP1A1; the disease is breast cancer.