KRT18 and neoplasm: As we reported previously that the compound oblongifolin C (OC), a PPAP purified from G. yunnanensis Hu, showed tumor inhibitory effects via different mechanisms: (i) activation of mitochondria-dependent apoptotic pathway [19]; (ii) inhibition of autophagic flux [37]; (iii) inhibition of metastasis via upregulation of keratin 18 and tubulins [38]; and induction of DNA damage and ER stress [39].