HLA-DRB1 and systemic lupus erythematosus: SLE is largely determined by heritable factors (>66%) with multiple risk alleles located in multiple genes of the major histocompatibility complex (MHC) region or the complement system [144] and associations of HLA-DRB1*03:01, *15:01, *08:01 and *14:01 with SLE have been consistently replicated [145,146,147,148].