In contrast to effects of low doses of acenocoumarol, acenocoumarol given at the dose of 150 μg/kg/dose was without beneficial effect on the pancreatitis-evoked changes of pancreatic weight (Figure 2), pancreatic blood flow (Figure 4), pancreatic DNA synthesis (Figure 5) serum activity of pancreatic enzymes (Figure 6 and Figure 7) and serum concentration of IL-1β (Figure 8). The gene discussed is IL1B; the disease is pancreatitis.