The latter findings suggest that VEGF deprivation can improve antigen presentation by promoting DC expression and activation; this, in turn, can induce the expansion of the effector T-cell compartment with long-term memory and high-tumor-specific killing activity and enable to achieve distant lymph-nodes and tumor sites, producing the chemotactic chemokines 19 and 21 recognized by the chemokine receptor (CCR)-7 expressed on the surface of these CTLs.39,40. This evidence concerns the gene VEGFA and neoplasm.