CD8A and cancer: While such studies demonstrate a correlation between CD8+ T cell infiltration, TLO densities, and patient survival, they also raise an interesting question regarding the function of cytotoxic T cells: Are tumour infiltrating CD8+ T cells better equipped to control cancer due to their education within tumour-associated TLOs? While further research is still needed in this area, a recent study of ovarian cancer showed that CD8+ tumor-infiltrating lymphocyte responses were increased in the presence of TLOs containing dense accumulations of plasma cells (62).