Based on a virus delivery of lentivirus (LV), Ma et al. [43] investigated the antitumor efficacy of secretory Tat-apoptin for HCC cells and found that most of the HCC xenograft tumors disappeared following the treatment of LV-secretory signal peptide (SP)-Tat-apoptin/GFP. Here, TAT is linked to hepatocellular carcinoma.