We observed a higher degree of portal hypertension in patients with higher levels of hepatic KRT23 expression compared to those with lower levels of hepatic KRT23 expression (hepatic venous pressure gradient 14 ± 6 mmHg vs. 21 ± 5 mmHg, respectively; P < 0.001) (Fig. 3d). The gene discussed is KRT23; the disease is liver disorder.