Tumor doubling time was prolonged from 4.93 days in mice receiving PBS, 5.45 days in mice receiving TRAIL, 6.63 days in mice receiving APG to 9.25 days in mice receiving APG + TRAIL (CI = 1.95; Fig. 7c), indicating a supra-additive or synergistic effect of APG and TRAIL. This evidence concerns the gene TNFSF10 and neoplasm.