Furthermore, expression of BacNav channels could ameliorate reduced cardiac tissue excitability and arrhythmogenic conduction slowing in various pathological conditions (for example, ischaemia, infarction and congenital disease) associated with membrane depolarization and inactivation of Nav1.5 channels2, 28, 29 or diminished intercellular coupling30, 31. This evidence concerns the gene SCN5A and ischemia.