RASA1 and breast carcinoma: For other cancer types, somatic inactivation of p120RasGAP was reported in thyroid, nasopharyngeal, esophageal and gastric cancer32, 33, 34, and a potential tumor suppressor role of p120RasGAP in basal cell carcinoma, and triple negative and HER2 positive subtypes of breast cancer was also suggested by genetic studies and integrative bioinformatics analysis35, 36.