In the T2D subjects, expression of 11 T2D-GWAS candidate genes (IRS1, WFS1, KCNQ1, CHCHD9, CDKN2A, SLC16A11, GPSM1, CCDC102A, IL2RB, PPARD, DNMT3A) were repressed in their PBMC (Table S3). The gene discussed is IRS1; the disease is type 2 diabetes mellitus.