ABCC8 and type 2 diabetes mellitus: Of note, the p-values of variants of genes targeted by anti-diabetic drugs (with the exception of IDE, PPARG, KCNJ11 and ABCC8, which are established T2D loci) were between 4.28E-5 and 6.75E-3 in the DIAGRAMv3 GWAS, not reaching genome-wide significance27.