Insulin signaling activates mTOR to increase hepatic gene expression through the mTORC2 complex, and lipogenesis by modulating gene expression of SREBF1. The formation of mTORC2 complex is dependent on MLST8 (or rictor) expression and disruption of mTORC2 by silencing MLST8 can lead to insulin resistance in rodent model23. This evidence concerns the gene SREBF1 and Insulin resistance.