We show that TRiC, previously shown to interact with mHtt monomers (Tam et al., 2009), large oligomers (Sontag et al., 2013) and fibrillar aggregates (Shahmoradian et al., 2013), promotes clearance of small 3B5H10-reactive mHtt oligomers (Figure 7E) confirming its crucial protective role in HD. This evidence concerns the gene MARVELD2 and Huntington disease.