MARVELD2 and Huntington disease: One established mechanism is the chaperonin TRiC/CCT, which suppresses mHtt aggregation and toxicity in many HD models through recognition of N17 by the CCT1 subunit (Behrends et al., 2006; Kitamura et al., 2006; Tam et al., 2006; Tam et al., 2009).