LRP6 and metabolic disease: Here we have studied the biogenesis of Low-density lipoprotein Receptor-related Protein 6 (LRP6), a key component of the canonical Wnt signaling pathway, which has been associated with many human pathologies including cancer, osteoporosis and metabolic diseases (Joiner et al., 2013), but also involved in the formation of gap junctions in cardiomyocytes (Li et al., 2016).