Consistent with their findings, pancreata of COX2 transgenic mice exhibited phenotypes similar to chronic pancreatitis such as the loss of the pancreatic acini, the increase of the metaplastic pancreatic ducts with dysplastic changes, periductal fibrosis, and mono-nuclear inflammatory cell infiltration in the highly vascularized fibrotic stroma (Fig. 6). This evidence concerns the gene PTGS2 and chronic pancreatitis.