While there was about ten-fold higher (p value ≤ 0.0018) number of cells in circulating peripheral blood at day 34 (Figure 5F, left panel), the NecroX2 treated T cells also secreted more (p value ≤ 0.0003) effector cytokine IFNγ (Figure 5F, right panel). Thus, our data firmly establishes that understanding the death pathway of effector T cells could be important in devising rationale strategies to target them for increased persistence and achieving better tumor control. This evidence concerns the gene IFNG and neoplasm.