FILIP1L and metastatic malignant neoplasm in the lymph nodes: Furthermore, higher FILIP1L levels were associated with reductions in tumor size, cell differentiation, lymphovascular invasion, cancer stage, depth of invasion, and lymph node metastasis (P = 0.019, < 0.001, 0.001, < 0.001, 0.005, and 0.002, respectively; Table 1).