Serum beta-2 microglobulin (B2MG), a small molecule protein, has been found elevated and associated with prognosis in many lymphoid malignancies [10–13], such as follicular lymphoma, NK/T-cell lymphoma, diffuse large B cell lymphoma (DLBCL) and mantle cell lymphoma. This evidence concerns the gene B2M and diffuse large B-cell lymphoma.