Treatment with BAY ACC002 (30 mg/kg/day for 7 days p.o.)in a Capan-2 pancreatic cancer xenograft mouse model suppressed mRNA expression of the WNT/β-catenin target gene AXIN2 by ∼60% and of the HH target gene GLI1 by 40% (Figure 3A). This evidence concerns the gene AXIN2 and familial pancreatic carcinoma.