As a matter of fact, in this distinct report, the authors presented evidence suggesting that MSCs from AML patients (AML-MSCs) are characterized by a more pronounced osteogenic phenotype, as showed by the increased expression of osteogenic specific markers, as Runx-2, osteopontin, tissue nonspecific alkaline phosphatase (TNAP) and osterix [145]. This evidence concerns the gene SPP1 and acute myeloid leukemia.