EGFR and non-small cell lung carcinoma: This genetic change has required the development of the third generation of EGFR-directed TKIs, that includes AZD9291 (osimertinib or mereletinib), CO-1686 (rociletinib), HM61713, ASP8273, EGF816, PF-06747775, all being effective in the therapy of NSCLC harboring mutated EGFR [28].