Alzheimer's disease (AD), the most common form of dementia in the elderly [1], is a neurodegenerative disorder that is pathologically characterized by deposition of extracellular amyloid-beta (Aβ) plaques, intracellular neurofibrillary tangle composed of hyperphosphorylated tau and massive neuronal loss [2, 3]. Here, MAPT is linked to Alzheimer disease.