We next assessed the effects of SkQ1 treatment on the levels of brain-derived neurotrophic factor (BDNF) and of neurotrophic receptors tyrosine kinase B (TrkB) and p75 neurotrophin receptor (p75NTR), because we recently reported [32] that in OXYS rats, the cerebral level of BDNF compensatory increases in response to the development of neurodegenerative changes at early stages of AD-like pathology and dramatically decreases with age. This evidence concerns the gene NGFR and Alzheimer disease.