Generally, the proportion of participants with diabetes receiving oral antidiabetic medication (OR2014 vs. 2000 = 2.50 [95%-CI: 1.44, 4.34]), blood pressure lowering medication and lipid lowering medication (OR2014 vs. 2000 = 3.50 [95% CI: 2.02, 6.06]) increased and the use of insulin significantly decreased from 2000 to 2014 (OR2014 vs. 2000 = 0.47 [95% CI: 0.22, 0.98]). The gene discussed is INS; the disease is diabetes mellitus.