CRP and coronary artery disorder: 27—beta-coefficients represent per allele associations with log-transformed CRP concentrations. Genetic associations with CAD risk were taken from the CARDIoGRAM consortium;28 beta-coefficients represent per allele log odds ratios for CAD risk. Ethical approval for the analyses using four genetic variants in the CRP gene region was granted by the Cambridgeshire ethics review committee; for the analyses using 17 genetic variants associated with CRP concentrations and with CAD risk, ethical approval was granted to the constituent studies by local institutional review boards.