TAL1 and cancer: An important part of the response to THZ1 appears to derive from the special sensitivity of cancer cells to transcriptional inhibition of key driver genes, as exemplified in T-cell acute lymphoblastic leukaemia cells.43 RUNX1, TAL1 and GATA3, which together constitute a critical transcriptional circuit in T-cell acute lymphoblastic leukaemia cells, were among the genes that were most sensitive to THZ1.