Animal models and human studies have shown that soluble oligomers of both Aβ‐ and FTD‐associated mutant tau contribute to synapse loss (Walsh et al., 2002; Shankar et al., 2008; Koffie et al., 2009, 2012; Kopeikina et al., 2011; Lasagna‐Reeves et al., 2011; Bilousova et al., 2016). Here, MAPT is linked to frontotemporal dementia.