The top 50 genes correlating with MenaCalc in the COAD cohort (Supplementary Table S1), including EMT markers Zeb1 and Zeb2, were enriched in gene sets related to EMT (Table 1), and were associated with GO terms such as cell:substrate adhesion (GO:0031589) and cell:matrix adhesion (GO:0007160) (Fig. 1D). Here, ZEB2 is linked to colon adenocarcinoma.