Mena11a is enriched in epithelia; we find it preferentially targets to cell:cell contacts in vivo (Fig. 1 and Supplementary Fig. S1), and co-localizes with ZO-1 at tight junctions (Fig. 2A) as well as E-cadherin at adherens junctions (Fig. 2B) in cultured human breast cancer MCF7 cells. This evidence concerns the gene TJP1 and breast carcinoma.