We compared our data set against the only other human picornavirus screen reported, the druggable genome screen for poliovirus and CB3 host factors by Coyne et al. 25 Despite the differences in virus species, cell lines used and scope of screen, we found at least three shared host factors, AKT2, RGS16 and SGK2. While their current roles in enteroviral infections are unknown, future studies should explore if these factors are involved in enteroviral infection specifically or viral infections in general. Here, RGS16 is linked to viral infectious disease.