25. reported that the risk factors related to intrasubsegmental recurrence after RFA were tumor size, AFP levels, platelet count, and anti‐HCV antibody positivity. The results of our study were not similar to those reported in the past report because in the past study, there was no imaging and pathological data collection before RFA. In addition, their cut‐off value for AFP‐L3 level was 15%. However, in the systematic review and meta‐analysis of AFP‐L3, the most frequently used cut‐off value of AFP‐L3 was 10% 15. The gene discussed is AFP; the disease is neoplasm.