AFP and neoplasm: Based on multivariate analysis, irregular pattern in MIP classification (HR  = 5.46; 95% confidence interval, CI = 1.23–24.4; P = 0.025) and serum AFP‐L3 index of >10% (HR = 5.10, 95% CI = 1.82–14.3, P = 0.002) before RFA were identified as independent risk factors for local tumor progression (Table 2).