AFP and hepatocellular carcinoma: In univariate and multivariate analyses, pretreatment AFP‐L3 level and irregular vascular pattern by CEUS were significant independent risk factors associated with multicentric recurrence for HCC (irregular pattern in MIP: HR = 3.82; 95% CI = 1.52–9.53; P = 0.004 and AFP‐L3 > 10%: HR = 1.72; 95% CI = 1.02–2.93; P = 0.043).