On the other hand, accumulated evidence indicate that the pathogenesis of some commonly occurring cancers, such as breast, or colon cancer, as well as of some types of lymphomas (malignant neoplasms of the lymphoid tissue), can be explained by the complex interplay of age-related and lifestyle-related mechanisms, operating mainly through chronic inflammation and impaired insulin dependent metabolism, known as insulin resistance condition (decreased insulin action in target tissues followed by chronic hyperglycemia) [48–50]. The gene discussed is INS; the disease is colonic neoplasm.