Furthermore, Li et al. have found that adenovirus-mediated PTEN (AdVPTEN) gene therapy and diamminedichloroplatinum treatment exerted an overlapping effect on the upregulation of P53, P21, P27, Bax, and cleaved caspase-3 in an animal model of small-cell lung cancer [15]. This evidence concerns the gene CASP3 and small cell lung carcinoma.