HMGB1 and neoplasm: Tumor products alpha-fetoprotein (AFP) and microRNAs (1, 2); biochemical enzymes corticosteroid-induced alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) (3, 4); cytokine tumor necrosis factor-α (TNF-α) (5); metabolic profiling by gas chromatography (6); leakage enzymes thymidine kinase 1 (TK1) and high-mobility group B1 proteins (HMGB1) (7, 8); and fucosylated serum proteins as well as serum proteins serum amyloid A (SAA), C-reactive protein (CRP), and haptoglobin (9–13) have been evaluated.