These authors showed that, in muscle tissue, DNAJB6 protein is primarily localized at the Z-disks, and that in LGMD1D patients a Z-disk myofibrillar disintegration was visible with accumulation of DNAJB6 and its known ligands MLF1 (myeloid leukemia factor 1), HSPA8 and KRT18 (keratin 18). This evidence concerns the gene MLF1 and Autosomal dominant limb-girdle muscular dystrophy type 1D.