These authors showed that, in muscle tissue, DNAJB6 protein is primarily localized at the Z-disks, and that in LGMD1D patients a Z-disk myofibrillar disintegration was visible with accumulation of DNAJB6 and its known ligands MLF1 (myeloid leukemia factor 1), HSPA8 and KRT18 (keratin 18). The gene discussed is DNAJB6; the disease is autosomal dominant limb-girdle muscular dystrophy type 1D (DNAJB6).