Another important work investigating the effects of the LGMD1D mutations, by Stein et al. (2014), exploited the yeast ortholog Hsp40 Sis1, creating a Sis1-DNAJB6 protein chimera in which the G/F domain of DNAJB6 was substituted to that of Sis1. The gene discussed is DNAJB6; the disease is autosomal dominant limb-girdle muscular dystrophy type 1D (DNAJB6).