Another important work investigating the effects of the LGMD1D mutations, by Stein et al. (2014), exploited the yeast ortholog Hsp40 Sis1, creating a Sis1-DNAJB6 protein chimera in which the G/F domain of DNAJB6 was substituted to that of Sis1. Here, DNAJB6 is linked to Autosomal dominant limb-girdle muscular dystrophy type 1D.