Exposure of MDA-MB-231 cells to D609 which is an inhibitor of a PC-PLC resulted in 60–80% PC-PLC inhibition associated with tumor cell differentiation, detected by a progressive decrease of mesenchymal traits such as vimentin and N-cadherin expression, reduced galectin-3 and milk fat globule EGF-factor 8 levels, β-casein formation and decreased in vitro cell migration and invasion (32). Here, HSPG2 is linked to neoplasm.