IL6 and ocular hypertension: Using IL-6−/− mice and our inducible, microbead occlusion model of ocular hypertension, we aim to determine whether IL-6 signaling plays a role in: 1) establishing baseline parameters for gp130-mediated signaling, neuroinflammation and cell health and 2) defining the nature and magnitude of IOP-induced neuroinflammatory, cell health and gp130-related regulatory signaling.