To determine whether IL-6-mediated changes in gp130 signaling impact the inflammatory, cell survival and gp130-related regulatory response of the retina to glaucomatous stressors, we examined gene expression of Tnfα, lL-1β,Bcl-xl, Bax and Socs3 in the Microbead Occlusion Model of murine glaucoma [17,20]. The gene discussed is SOCS3; the disease is glaucoma.