To test whether mitophagy is involved in mitochondrial changes in cancer cells, we analyzed the mitophagy marker BNIP3 [30, 43] and found that its protein level was 7.9-fold elevated (p < 0.001) in MDA-MB-231 cells when it was compared with that in MCF-10A cells (Figures 4(a) and 4(b)). The gene discussed is BNIP3; the disease is cancer.