The major findings of the present study are as follows: (1) RD significantly inhibited the decrease in BP in the development of ISO-induced HF and favorably altered autonomic regulation, including increase in HR variability and BRS and decrease in BP variability; (2) RD significantly inhibited ISO-induced increases in mRNA and protein expression of RAS components and PICs in the LT and PVN, two forebrain nuclei involved in regulation of BP and sympathetic activity; (3) central blockade of either AT1-R or TNF-α partially mimicked the beneficial actions of RD in the ISO-induced HF. Here, TNF is linked to hydrops fetalis.