MYO9B and celiac disease: In addition, MYO9B is a good candidate gene for therapy in celiac disease as its encoded protein is involved in early mucosal inflammatory response. MYO9B-encoded protein belongs to class IX myosin molecules, which contains a Rho-GTPase-activating domain and regulates Rho/ROCK-dependent remodeling of cytoskeleton and epithelial permeability [5, 83].