Interestingly, ~36% of these targets were found to be altered at the transcript (BCL2, CCNE1, CSKN2A1, ELAVL1, ERBB2, ETS1, EZH2, FOXO1, IRAK1, MUC1, MYC, NDRG1, PDCD4, SERPINB5, RPS6B1, SNCG, TIMP3, TP53, and TP53INP1) or the protein (BCL2, CASP3, CCNE1, CDKN1B, ERBB2, MUC1, MYC, PTEN, SERPINB5, TP53) levels in breast cancer based on analyses using genes to system breast cancer (G2SBC) database (Mosca et al., 2010). The gene discussed is CASP3; the disease is breast cancer.