Although other studies showed that nerve growth factor IB (Nur77), nuclear receptor related1 (Nurr1) and N-methyl-d-aspartate (NMDA) receptors also regulated neuroprotective signaling after neuronal injury of neurodegenerative disease (Tell and Hilgeroth, 2013; Wang et al., 2014; Wei et al., 2015), our study found that more nestin+ cells migrate from the SVZ to the infarct area in NT-1 group than that of the other two groups. Here, NES is linked to neurodegenerative disease.