PARP1 and cancer: rs8689 is located at 5.3 kb upstream to 3′UTR region of PARP-1 and is in LD (r2 > 0.8) with PARP-1 SNPs rs2271347 (r2 = 1), rs61835377 (r2 = 1), rs1805403 (r2 = 1), and rs2793383 (r2 = 0.945), which has been shown to be associated with increased risk for several cancers and other diseases.