ZNF652 was upregulated by hypoxia in IPF but not in normal lung fibroblasts (Fig E9, F) and in contrast to LXRα, the expression of ZNF652 correlated negatively with miR-155 expression (Fig E9, G), suggesting that under hypoxic stress, miR-155 may be preferentially bound by the increased ZNF652 leading to derepression of LXRα in IPF fibroblasts. This evidence concerns the gene NR1H3 and idiopathic pulmonary fibrosis.