Under hypoxic conditions, the expression levels of miR-155 correlated negatively with LXRα in control lung fibroblasts, implying tight epigenetic control, whereas there was no equivalent engagement between miR-155 and LXRα in IPF fibroblasts, thus enabling continued LXRα autoactivation41 and profibrotic behavior. Here, NR1H3 is linked to idiopathic pulmonary fibrosis.