No potentially pathogenic mutations in C1R or C1S were identified in families 18 and 19, previously reported to be affected by pEDS but not available for clinical re-assessment,5, 19 in 11 individuals clinically diagnosed with vascular EDS, or in 71 individuals diagnosed with aggressive periodontitis but without EDS-like features. Here, C1R is linked to Ehlers-Danlos syndrome, vascular type.