Among these, the rs738409 C>G (I148M) variant of the patatin like phospholipase domain containing 3 (PNPLA3) gene located at 22q13 is the most well validated association, influencing degree of steatosis, grade of inflammation, stage of fibrosis and risk of HCC [7-11]. The gene discussed is PNPLA3; the disease is hepatocellular carcinoma.