The PNPLA3 mRNA level did not significantly modify the risk of NAFLD conferred by rs738409 (main effect of PNPLA3 mRNA level on NAFLD p = 0.61; interaction between rs738409 and PNPLA3 mRNA level with respect to NAFLD (p = 0.97). Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.