SIRT1 and coronary artery disorder: In addition, Breitenstein et al. demonstrated that Sirt1 mRNA expression is decreased in peripheral blood monocytes isolated from patients either with angiographically confirmed coronary artery disease and/or presenting with acute coronary syndrome compared with mono-cytes isolated from healthy subjects [68], and the expression of IL-6 was increased in patients with impaired Sirt1 expression.