Donato et al. previously reported that Sirt1 expression is reduced in endothelial cells obtained from arteries of older human adults (64 ± 1 years) compared to those from younger adults (25 ± 1 years), and reduced endothelial Sirt1 expression with aging may be related to endothelial dysfunction through the impairment of NO production from eNOS [47]. The gene discussed is SIRT1; the disease is endothelial dysfunction.