Gorenne et al. showed that endogenous Sirt1 is reduced in human atherosclerosis, particularly in VSMCs [75] Sirt1 deficiency reduces DNA repair and promotes the activation of DNA damage markers and senescence via reduced activation of the repair protein Nijmegen breakage syndrome-1 (NBS-1) due to decreased deacetylation. This evidence concerns the gene SIRT1 and atherosclerosis.